won the 1969 Lasker Prize.Once L-DOPA has entered the central nervous system, it is converted into dopamine by the enzyme aromatic L-amino acid decarboxylase, also known as DOPA decarboxylase. Pyridoxal phosphate (vitamin B6) is a required cofactor in this reaction, and may occasionally be administered along with L-DOPA, usually in the form of pyridoxine.
Besides the central nervous system, L-DOPA is also converted into dopamine from within the peripheral nervous system. Excessive peripheral dopamine signaling causes many of the adverse side effects seen with sole L-DOPA administration. To bypass these effects, it is standard clinical practice to coadminister (with L-DOPA) a peripheral DOPA decarboxylase inhibitor (DDCI) such as carbidopa (medicines containing carbidopa, either alone or in combination with L-DOPA, are branded as Lodosyn(Aton Pharma) Sinemet (Merck Sharp & Dohme Limited), Pharmacopa (Jazz Pharmaceuticals), Atamet (UCB), and Stalevo (Orion Corporation) or with a benserazide (combination medicines are branded Madopar or Prolopa),to prevent the peripheral synthesis of dopamine from L-DOPA. Coadministration of pyridoxine without a DDCI accelerates the peripheral decarboxylation of L-DOPA to such an extent that it negates the effects of L-DOPA administration, a phenomenon that historically caused great confusion.
In addition, L-DOPA, co-administered with a peripheral DDCI, has been investigated as a potential treatment for restless leg syndrome. However, studies have demonstrated "no clear picture of reduced symptoms".
Function :
1.Mucuna Pruriens Extract Levodopa can be used as dietary supplements.
2.Mucuna Pruriens Extract Levodopa is used as a component in marine adhesives used by pelagic life.
3.Mucuna Pruriens Extract Levodopa can promote muscle growth,loss weight,and increased bone density and reversal of osteoporosis.
4.Mucuna Pruriens Extract Levodopa increase bone density and reversal of osteoporosis,increase muscle strength,enhance libido and sexual performance.
5.In clinical use, Mucuna Pruriens Extract Levodopa is administered in the management of Parkinson's disease and dopa-responsive dystonia.
Application :
1.Levodopa can be applied in health supplement.
2. Levodopa can be applied in functional food additive.
3. Levodopa can be applied in cosmetics and personal care products.
4.Levodopa can be applied in hair coloring .
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